Article
Father-to-mother-to-infant transmission of HIV-1: clonally transmitted isolate of infant mutates more rapidly than that of the mother and rapidly loses reactivity with neutralizing antibody.
Microbiology and immunology - 1 Jan 1997
Okamoto Y, Shiosaki K, Eda Y, Tokiyoshi S, Yamaguchi Y, Gojobori T, Hachimori T, Yamazaki S, Hondo M
Abstract excerpt
The sequences of the V3 loop and surrounding regions of human immunodeficiency virus type-1 from a father-to-mother-to-infant trimmer were studied and the horizontal and vertical transmissions compared. The father's virus was variable for reactivity with neutralizing antibody and sequences of the V3 loop central core sequence. In contrast, the mother's viral sequences were much less diverse and reacted with a...
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