Article
Aberrant methylation of an imprinted gene U2af1-rs1(SP2) caused by its own transgene.
The Journal of biological chemistry - 4 Apr 1997
Hatada I, Nabetani A, Arai Y, Ohishi S, Suzuki M, Miyabara S, Nishimune Y, Mukai T
Abstract excerpt
Genomic imprinting refers to the parental allele-specific expression of genes. The precise mechanism underlying this phenomenon, which may involve DNA methylation, is not yet known. U2af1-rs1(SP2) is an imprinted gene expressed from the paternal allele and is methylated on the maternal allele. Here we report an artificial system in which expression and methylation of the endogenous imprinted gene U2af1-rs1 can be...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.