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Article

A role for destabilizing amino acid replacements in light-chain amyloidosis.

7 Jun 1994

Abstract excerpt

Light-chain (L-chain) amyloidosis is characterized by deposition of fibrillar aggregates composed of the N-terminal L-chain variable region (VL) domain of an immunoglobulin, generally in individuals overproducing a monoclonal L chain. In addition to proteolytic fragmentation and high protein concentration, particular amino acid substitutions may also contribute to the tendency of an L chain to aggregate in...

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Identifiers

PMID: 8202506
DOI: 10.1073/pnas.91.12.5446

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