Article
Use of monoclonal antibodies to detect disease associated HLA-DRB1 alleles and the shared epitope in rheumatoid arthritis.
Annals of the rheumatic diseases - 1 Feb 1997
Wicks I, McColl G, D'Amico A, Dougherty L, Tait B
Abstract excerpt
OBJECTIVE: To use a panel of monoclonal antibodies (Mab) which recognise HLA class II alleles associated with rheumatoid arthritis for fluorescence activated cell sorter (FACS) analysis of peripheral blood mononuclear cells (PBMNC) from patients with early and established rheumatoid arthritis and to compare these results against DNA oligotyping of HLA class II molecules in the same patients. METHODS: 27 patients...
Topics
- Alleles
- Antibodies, Monoclonal
- Arthritis, Rheumatoid
- Cell Separation
- Epitopes
- Flow Cytometry
- HLA-DR Antigens
- HLA-DRB1 Chains
- Histocompatibility Testing
- Humans
- Prognosis