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Article

Single amino acid substitutions in the glycoprotein B carboxy terminus influence the fusion from without property of herpes simplex virus type 1.

The Journal of general virology - 1 Jul 1995

Lingen M, Seck T, Weise K, Falke D

Abstract excerpt

Syncytial mutations of herpes simplex virus type 1 (HSV-1) strains ANG, ANG path, HFEM, tsB5 and HSZP cause extensive cell fusion and were mapped to the cytoplasmic domain of glycoprotein B (gB), within the syn 3 locus. These strains are so far the only ones which show the phenotype 'fusion from without' (FFWO): 60 min after infection with high m.o.i., cells in a tissue culture are fused without transcription and...

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Identifiers

PMID: 9049391
DOI: 10.1099/0022-1317-76-7-1843

Genes

ANG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single amino acid substitutions in the glycoprotein B carboxy terminus influence the fusion from without property of herpes simplex virus type 1.PMID 9049391Read ↗

Identification of the fusion-from-without determinants of herpes simplex virus type 1 glycoprotein B.Semantic proximity Read ↗

Cyclosporin A resistance of herpes simplex virus-induced "fusion from within" as a phenotypical marker of mutations in the Syn 3 locus of the glycoprotein B gene.Semantic proximity Read ↗

Amino acid substitutions in glycoprotein D mediate the ability of fusion from without-positive herpes simplex virus type 1 strains to penetrate at 4 degrees and in the presence of soluble glycoprotein D.Semantic proximity Read ↗

Two mutations in gB-1 and gD-1 of herpes simplex virus type 1 are involved in the "fusion from without" phenotype in different cell types.Semantic proximity Read ↗

Herpes Simplex Virus 1 Glycoprotein B from a Hyperfusogenic Virus Mediates Enhanced Cell–Cell FusionSemantic proximity Read ↗

Analysis of the contributions of herpes simplex virus type 1 membrane proteins to the induction of cell-cell fusion.Semantic proximity Read ↗

The glycoprotein B gene and its syn3 locus of herpes simplex virus type 1 are involved in the synthesis of virus-associated growth factor (HSGF-1).Semantic proximity Read ↗

A Virus Genetic System To Analyze the Fusogenicity of Human Cytomegalovirus Glycoprotein B VariantsSemantic proximity Read ↗

Truncation of herpes simplex virus type 2 glycoprotein B increases its cell surface expression and activity in cell-cell fusion, but these properties are unrelated.Semantic proximity Read ↗

Membrane fusion activity of herpes simplex virus 1 glycoproteins from a hyperfusogenic virusSemantic proximity Read ↗

Two novel single amino acid syncytial mutations in the carboxy terminus of glycoprotein B of herpes simplex virus type 1 confer a unique pathogenic phenotype.Semantic proximity Read ↗

Herpes simplex virus (HSV) glycoproteins B and K inhibit cell fusion induced by HSV syncytial mutants.Semantic proximity Read ↗

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