Article
Variation of the hepatitis C virus 5' non-coding region: implications for secondary structure, virus detection and typing. The International HCV Collaborative Study Group.
The Journal of general virology - 1 Jul 1995
Smith D B, Mellor J, Jarvis L M, Davidson F, Kolberg J, Urdea M, Yap P L, Simmonds P
Abstract excerpt
Variation in the 5' non-coding region (5'NCR) of hepatitis C virus (HCV) was investigated in detail by comparing 314 5'NCR sequences of viruses of genotypes 1 to 6. Evidence was obtained for the existence of associations between particular 5'NCR sequence motifs and virus types and subtypes. No recombination was observed between the 5'NCR and coding regions of different genotypes, implying that the sequence of...
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