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Article

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.

The Journal of general virology - 1 Nov 1993

Simmonds P, Holmes E C, Cha T A, Chan S W, McOmish F, Irvine B, Beall E, Yap P L, Kolberg J, Urdea M S

Abstract excerpt

Hepatitis C virus (HCV) showed substantial nucleotide sequence diversity distributed throughout the viral genome, with many variants showing only 68 to 79% overall sequence similarity to one another. Phylogenetic analysis of nucleotide sequences derived from part of the gene encoding a non-structural protein (NS-5) has provided evidence for six major genotypes of HCV amongst a worldwide collection of 76 samples...

Topics

Base Sequence
Genotype
Hepacivirus
Humans
Molecular Sequence Data
Phylogeny
RNA, Viral
Sequence Homology, Nucleic Acid
Viral Nonstructural Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 8245854
DOI: 10.1099/0022-1317-74-11-2391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8245854-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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