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Article

Classification of hepatitis C virus into six major genotypes and a series of subtypes by phylogenetic analysis of the NS-5 region.

The Journal of general virology - 1 Nov 1993

Simmonds P, Holmes E C, Cha T A, Chan S W, McOmish F, Irvine B, Beall E, Yap P L, Kolberg J, Urdea M S

Abstract excerpt

Hepatitis C virus (HCV) showed substantial nucleotide sequence diversity distributed throughout the viral genome, with many variants showing only 68 to 79% overall sequence similarity to one another. Phylogenetic analysis of nucleotide sequences derived from part of the gene encoding a non-structural protein (NS-5) has provided evidence for six major genotypes of HCV amongst a worldwide collection of 76 samples...

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PMID: 8245854
DOI: 10.1099/0022-1317-74-11-2391

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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