Article
Phenotype in Candida albicans of a disruption of the BGL2 gene encoding a 1,3-beta-glucosyltransferase.
Microbiology (Reading, England) - 1 Feb 1997
Sarthy Aparna V, McGonigal Thomas, Coen Michael, Frost David J, Meulbroek Jonathan A, Goldman Robert C
Abstract excerpt
The BGL2 gene encodes a unique 1,3-beta-glucosyltransferase (Bgl2p) present in the cell wall of Candida albicans and other fungi. Although believed to be involved in cell wall assembly, disruption of the gene in saccharomyces cerevisiae showed no apparent phenotype. We performed sequential disrup...
Topics
- Animals
- Antifungal Agents
- Candida albicans
- Candidiasis
- Cell Wall
- Fungal Proteins
- Genes, Fungal
- Glucan Endo-1,3-beta-D-Glucosidase
- Glucans
- Glucosyltransferases
- Glycosylation
- Kidney
- Mice
- Microbial Sensitivity Tests
- Mutagenesis
- Phenotype
- Virulence