Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees.

doi:10.1161/01.hyp.0000037131.41957.a8

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Article

Genomic association/linkage of sodium lithium countertransport in CEPH pedigrees.

Hypertension (Dallas, Tex. : 1979) - 1 Nov 2002

Schork Nicholas J, Gardner Jeffrey P, Zhang Li, Fallin Danielle, Thiel Bonnie, Jakubowski Hieronim, Aviv Abraham

Abstract excerpt

Little is known about genetic determinants explaining variation in the erythrocyte sodium-lithium countertransport (SLC), an intermediate phenotype of essential hypertension. We characterized the SLC in immortalized lymphoblasts and showed that its behavior is similar to that of erythrocyte SLC. We then performed association and linkage analyses of the SLC in immortalized lymphoblasts from 5 large pedigrees from...

Topics

Alleles
Angiotensinogen
Antiporters
Cell Line, Transformed
Chromosome Mapping
Erythrocytes
Ethylmaleimide
Female
Genetic Linkage
Genetic Markers
Genotype
Glutathione
Herpesvirus 4, Human
Humans

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ion Transport

Lithium

Lymphocytes

Male

Source

Open in PubMed

Identifiers

PMID: 12411453
DOI: 10.1161/01.hyp.0000037131.41957.a8

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