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Article

Liddle's disease: abnormal regulation of amiloride-sensitive Na+ channels by beta-subunit mutation.

The American journal of physiology - 1 Jan 1996

Bubien J K, Ismailov I I, Berdiev B K, Cornwell T, Lifton R P, Fuller C M, Achard J M, Benos D J, Warnock D G

Abstract excerpt

Liddle's disease is an autosomal dominant genetic disorder characterized by severe low renin hypertension ("pseudoaldosteronism") that has been genetically linked to a locus on chromosome 16 encoding the beta-subunit of an amiloride-sensitive Na+ channel (ASSC) (15). Peripheral blood lymphocytes (PBL) express ASSC that are functionally indistinguishable from those expressed by Na(+)-reabsorbing renal epithelial...

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Identifiers

PMID: 8772446
DOI: 10.1152/ajpcell.1996.270.1.C208

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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