Article
Selection of T lymphocytes bearing limited TCR-Vbeta regions in the lung of hypersensitivity pneumonitis and sarcoidosis.
American journal of respiratory and critical care medicine - 1 Feb 1997
Trentin L, Zambello R, Facco M, Tassinari C, Sancetta R, Siviero M, Cerutti A, Cipriani A, Marcer G, Majori M, Pesci A, Agostini C, Semenzato G
Abstract excerpt
Hypersensitivity pneumonitis (HP) and sarcoidosis are interstitial lung disorders (ILD) characterized by a lymphocytic alveolitis that, in the active phase of the disease, is sustained by different T-cell subsets, i.e., CD8+ cells in HP and CD4+ lymphocytes in sarcoid patients. To address the question of whether a bias in T-cell selection occurs in the lung of patients with HP and sarcoidosis, we analyzed the...
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