Article
A selection system to study C5a-C5a-receptor interactions: phage display of a novel C5a anaphylatoxin, Fos-C5aAla27.
Gene - 15 Jan 1997
Hennecke M, Kola A, Baensch M, Wrede A, Klos A, Bautsch W, Köhl J
Abstract excerpt
Binding and effector domains of the human anaphylatoxin C5a have been determined by either site directed mutagenesis or synthetic peptide studies. However, the lack of specific selection methods, which allow direct investigation of C5a-C5a-receptor interaction made these studies laborious. To overcome these limitations we have constructed a novel Fos-C5a expressed on the tip of a filamentous phage. To guarantee...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.