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Article

Exploring the Carbamazepine Interaction with Human Pregnane X Receptor and Effect on ABCC2 Using in Vitro and in Silico Approach.

Pharmaceutical research - 1 Jul 2017

Grewal Gurpreet K, Singh Khuraijam D, Kanojia Neha, Rawat Chitra, Kukal Samiksha, Jajodia Ajay, Singhal Anshika, Misra Richa, Nagamani Selvaraman, Muthusamy Karthikeyan, Kukreti Ritushree

Abstract excerpt

PURPOSE: Over expression of ATP-binding cassette transporters is considered one of the major reasons for non-responsiveness to antiepileptic drugs. Carbamazepine (CBZ), one of first line antiepileptic drug is known to influence ABCC2 expression but its exact molecular mechanism is unknown. METHODS: We investigated the effect of CBZ on expression of ABCC2 and pregnane X receptor (PXR) in HepG2 cell line and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28432535
DOI: 10.1007/s11095-017-2161-z

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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