Article
Molecular defects in Hb H hydrops fetalis.
British journal of haematology - 1 Feb 1997
Chan V, Chan V W, Tang M, Lau K, Todd D, Chan T K
Abstract excerpt
The molecular defect in two unique cases of Hb H hydrops fetalis has been characterized. Both cases are due to co-inheritance of a 'non-deletion' defect affecting the alpha2 gene: at codon 30 delta GAG, Glu) and codon 59 (G --> A, Gly --> Asp) respectively, and a zeta-alpha thalassaemia (thal) 1...
Topics
- Gene Deletion
- Globins
- Hemoglobin H
- Humans
- Hydrops Fetalis
- Mutation
- Polymerase Chain Reaction
- Prenatal Diagnosis