Hemoglobin Bart’s hydrops fetalis: charting the past and envisioning the future

doi:10.1182/blood.2023023692

Article

Hemoglobin Bart’s hydrops fetalis: charting the past and envisioning the future

8 Mar 2024

Abstract excerpt

ABSTRACT: Hemoglobin Bart's hydrops fetalis syndrome (BHFS) represents the most severe form of α-thalassemia, arising from deletion of the duplicated α-globin genes from both alleles. The absence of α-globin leads to the formation of nonfunctional hemoglobin (Hb) Bart's (γ4) or HbH (β4) resulting in severe anemia, tissue hypoxia, and, in some cases, variable congenital or neurocognitive abnormalities. BHFS is the...

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