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Article

Hb Dartmouth (HBA2: c.200T>C): An α2-Globin Gene Associated with Hb H Disease in One Homozygous Patient.

Hemoglobin - 1 Jan 2015

Farashi Samaneh, Faramarzi Garous Negin, Ashki Mehri, Vakili Shadi, Zeinali Fatemah, Imanian Hashem, Azarkeivan Azita, Najmabadi Hossein

Abstract excerpt

Hb H (β4) disease is caused by deletion or inactivation of three out of four α-globin genes. A high incidence of Hb H disease has been reported all over the world. There is a wide spectrum of phenotypic presentations, from clinically asymptomatic to having significant hepatosplenomegaly and requiring occasional or even regular blood transfusions, even more severe anemia, Hb Bart's (γ4) hydrops fetalis syndrome...

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Source

Identifiers

PMID: 25976777
DOI: 10.3109/03630269.2015.1027915

Genes

HBA2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

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