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Article

Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.

Genomics - 15 Jan 1997

Hughes D C, Allen J, Morley G, Sutherland K, Ahmed W, Prosser J, Lettice L, Allan G, Mattei M G, Farrall M, Hill R E

Abstract excerpt

The GLI family of zinc finger genes has been implicated in both neoplastic and developmental disorders. We have cloned and sequenced the mouse homolog of the zinc finger gene Gli2 and demonstrated significant similarity to the human GLI3 gene. We have also localized Gli2 to mouse chromosome 1, in the vicinity of the morphogenetic mutation Dominant hemimelia (Dh), which is characterized by tibial hemimelia,...

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Source

Identifiers

PMID: 9027508
DOI: 10.1006/geno.1996.4468

Genes

GLI3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Cloning and sequencing of the mouse Gli2 gene: localization to the Dominant hemimelia critical region.PMID 9027508Read ↗

The mouse mutant Polydactyly Nagoya (Pdn) defines a novel allele of the zinc finger gene Gli3.Semantic proximity Read ↗

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High-resolution mapping of the Gli3 mutation extra-toes reveals a 51.5-kb deletion.Semantic proximity Read ↗

Tibial hemimelia associated with GLI3 truncation.Semantic proximity Read ↗

A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2.Semantic proximity Read ↗

Loss-of-function mutations in the human GLI2 gene are associated with pituitary anomalies and holoprosencephaly-like features.Semantic proximity Read ↗

GliFHV mice: a tool to investigate GLI processing and localization.Semantic proximity Read ↗

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Expression of human GLI in mice results in failure to thrive, early death, and patchy Hirschsprung-like gastrointestinal dilatation.Semantic proximity Read ↗

Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt).Semantic proximity Read ↗

A novel gene, GliH1, with homology to the Gli zinc finger domain not required for mouse development.Semantic proximity Read ↗

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