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Article

Molecular basis of artifacts in the detection of telomerase activity and a modified primer for a more robust 'TRAP' assay

15 Feb 1997

Abstract excerpt

Human somatic cells have essentially no telomerase activity. Telomerase is linked to tumor genesis and is a valuable marker for malignant growth. Extreme paucity of the enzyme neccessitated development of a PCR-based assay, 'telomeric repeat amplification protocol' (TRAP). Unfortunately, this method is not without difficulties. Amplification products are not related to the size of the amplified telomerase...

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PMID: 9016650
DOI: 10.1093/nar/25.4.919

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