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Article

Measurement of Telomerase Activity in Dog Tumors

1 Jan 1999

Abstract excerpt

Telomeres are specific structures present at the end of liner chromosomes. DNA polymerase can not synthesize the end of liner DNA and, as a result, the telomeres become progressively shortened by successive cell divisions. To overcome the end replication problem, telomerase adds new telomeric sequences to the end of chromosomal DNA. The enzyme activity is undetectable in most normal human adult somatic cells, in...

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PMID: 10563290
DOI: 10.1292/jvms.61.1125

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