Article
Promoter strength influences phase variation of neisserial opa genes.
Molecular microbiology - 1 Jan 1997
Belland R J, Morrison S G, Carlson J H, Hogan D M
Abstract excerpt
The opa multigene family of Neisseria gonorrhoeae encodes 11 related outer-membrane proteins which phase vary in vitro and in vivo. Illegitimate recombination within direct pentameric DNA repeats, encoding the signal-peptide region of pre-Opas, leads to switches in expression states. Despite the conserved nature of the variation mechanism, specific genes are expressed at high frequencies in the transition from...
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