Promoter strength influences phase variation of neisserial opa genes.

doi:10.1046/j.1365-2958.1997.1971556.x

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Article

Promoter strength influences phase variation of neisserial opa genes.

Molecular microbiology - 1 Jan 1997

Belland R J, Morrison S G, Carlson J H, Hogan D M

Abstract excerpt

The opa multigene family of Neisseria gonorrhoeae encodes 11 related outer-membrane proteins which phase vary in vitro and in vivo. Illegitimate recombination within direct pentameric DNA repeats, encoding the signal-peptide region of pre-Opas, leads to switches in expression states. Despite the...

Topics

Antigens, Bacterial
Bacterial Outer Membrane Proteins
Cloning, Molecular
Escherichia coli
Gene Expression Regulation, Bacterial
Genetic Variation
Lac Operon
Neisseria gonorrhoeae
Promoter Regions, Genetic
RNA, Bacterial
RNA, Messenger
Sequence Analysis, DNA

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