Variable expression of class 1 outer membrane protein in Neisseria meningitidis is caused by variation in the spacing between the -10 and -35 regions of the promoter.

Abstract excerpt

The class 1 outer membrane protein encoded by the porA gene of Neisseria meningitidis is a candidate for a vaccine against meningococcal infection. The expression of class 1 outer membrane protein displays phase variation between three expression levels. Northern (RNA) blot and primer extension analysis revealed that this phase variation is regulated at the transcriptional level. The start site for transcription...

Topics

• Bacterial Vaccines
• Base Sequence
• Gene Expression Regulation, Bacterial
• Genes, Bacterial
• Genetic Variation
• Molecular Sequence Data
• Mutagenesis
• Neisseria meningitidis
• Poly G
• Porins