Article
Effect of genotype on the levels of surfactant protein A mRNA and on the SP-A2 splice variants in adult humans.
The Biochemical journal - 1 Jan 1997
Karinch A M, deMello D E, Floros J
Abstract excerpt
Human pulmonary surfactant protein A (SP-A) is encoded by two genes, SP-A1 and SP-A2, that exhibit coding sequence (allelic) and 5' splicing variability. In this report we determine the effect of the genetic variability within the SP-A1 and SP-A2 genes on the level of SP-A mRNAs and on the SP-A2 splicing variants in different individuals. We analysed mRNA specimens from 23 unrelated adults using genotype...
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