Article
IK of rabbit ventricle is composed of two currents: evidence for IKs.
The American journal of physiology - 1 Dec 1996
Salata J J, Jurkiewicz N K, Jow B, Folander K, Guinosso P J, Raynor B, Swanson R, Fermini B
Abstract excerpt
The delayed rectifier K+ current (IK) in rabbit heart has long been thought to consist of only a single, rapidly activating, dofetilide-sensitive current, IKr. However, we find that IK of rabbit ventricular myocytes actually consists of both rapid and slow components, IKr and IKs, respectively, that can be isolated pharmacologically. Thus, after complete blockade of IKr with dofetilide, the remaining current,...
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