Article
Role of early and late replication events in induction of apoptosis by baculoviruses.
Journal of virology - 1 Feb 1997
LaCount D J, Friesen P D
Abstract excerpt
Autographa californica nuclear polyhedrosis virus (AcMNPV) mutants that lack the apoptotic suppressor gene p35 cause apoptosis in Spodoptera frugiperda SF21 cells. To identify a viral signal(s) that induces programmed cell death, we first defined the timing of apoptotic events during infection. Activation of a P35-inhibitable caspase, intracellular fragmentation of host and AcMNPV DNA, and cell membrane blebbing...
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