Article
Persistent baculovirus infection results from deletion of the apoptotic suppressor gene p35.
Journal of virology - 1 Nov 1998
Lee J C, Chen H H, Chao Y C
Abstract excerpt
Infection with the wild-type baculovirus Autographa californica multiple nuclear polyhedrosis virus (AcMNPV) results in complete death of Spodoptera frugiperda (Sf) cells. However, infection of Sf cells with AcMNPV carrying a mutation or deletion of the apoptotic suppressor gene p35 allowed the cloning of surviving Sf cells that harbored persistent viral genomes. Persistent infection established with the virus...
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