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Article

Transmission of the BSE agent to mice in the absence of detectable abnormal prion protein.

Science (New York, N.Y.) - 17 Jan 1997

Lasmézas C I, Deslys J P, Robain O, Jaegly A, Beringue V, Peyrin J M, Fournier J G, Hauw J J, Rossier J, Dormont D

Abstract excerpt

The agent responsible for transmissible spongiform encephalopathies (TSEs) is thought to be a malfolded, protease-resistant version (PrPres) of the normal cellular prion protein (PrP). The interspecies transmission of bovine spongiform encephalopathy (BSE) to mice was studied. Although all of the mice injected with homogenate from BSE-infected cattle brain exhibited neurological symptoms and neuronal death, more...

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Identifiers

PMID: 8994041
DOI: 10.1126/science.275.5298.402

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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