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Article

Emergence of a novel bovine spongiform encephalopathy (BSE) prion from an atypical H-type BSE.

Scientific reports - 7 Mar 2016

Masujin Kentaro, Okada Hiroyuki, Miyazawa Kohtaro, Matsuura Yuichi, Imamura Morikazu, Iwamaru Yoshifumi, Murayama Yuichi, Yokoyama Takashi

Abstract excerpt

The H-type of atypical bovine spongiform encephalopathy (H-BSE) was serially passaged in bovinized transgenic (TgBoPrP) mice. At the fourth passage, most challenged mice showed a typical H-BSE phenotype with incubation periods of 223 ± 7.8 days. However, a different phenotype of BSE prion with shorter incubation periods of 109 ± 4 days emerged in a minor subset of the inoculated mice. The latter showed distinct...

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Identifiers

PMID: 26948374
DOI: 10.1038/srep22753
PMCID: PMC4780101

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