Article
Experimental Infection of Cattle With a Novel Prion Derived From Atypical H-Type Bovine Spongiform Encephalopathy.
Veterinary pathology - 1 Nov 2017
Okada Hiroyuki, Masujin Kentaro, Miyazawa Kohtaro, Iwamaru Yoshihumi, Imamura Morikazu, Matsuura Yuichi, Arai Shozo, Fukuda Shigeo, Murayama Yuichi, Yokoyama Takashi
Abstract excerpt
H-type bovine spongiform encephalopathy (H-BSE) is an atypical form of BSE in cattle. During passaging of H-BSE in transgenic bovinized (TgBoPrP) mice, a novel phenotype of BSE, termed BSE-SW emerged and was characterized by a short incubation time and host weight loss. To investigate the biological and biochemical properties of the BSE-SW prion, a transmission study was conducted in cattle, which were inoculated...
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