Article
Zn2+ promotes the self-association of human immunodeficiency virus type-1 integrase in vitro.
Biochemistry - 7 Jan 1997
Lee S P, Xiao J, Knutson J R, Lewis M S, Han M K
Abstract excerpt
It has been recently demonstrated that the Mg(2+)-dependent 3'-processing activity of purified human immunodeficiency virus type-1 (HIV-1) integrase is stimulated by the addition of exogenous Zn2+ [Lee, S. P., & Han, M. K. (1996) Biochemistry 35, 3837-3844]. This activation was hypothesized to result from integrase self-association. In this report, we examine the Zn2+ content of purified HIV-1 integrase by atomic...
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