Role of Alveolar Macrophages in Rapid Elimination of Adenovirus Vectors Administered to the Epithelial Surface of the Respiratory Tract

Abstract excerpt

To evaluate the hypothesis that innate immune mechanisms play a major role in eliminating adenovirus (Ad) vectors from the lung, the fate of adenoviral genome of an Ad vector was quantified in the first 24 h after intratracheal administration of an Ad vector coding for beta-galactosidase (beta gal) to mice. Southern analysis with an Ad specific probe showed that 70% of the Ad genome was lost within 24 h, in both...

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