Article
Conservation of topology, but not conformation, of the proteolipid proteins of the myelin sheath.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 1997
Gow A, Gragerov A, Gard A, Colman D R, Lazzarini R A
Abstract excerpt
The proteolipid protein gene products DM-20 and PLP are adhesive intrinsic membrane proteins that make up >/=50% of the protein in myelin and serve to stabilize compact myelin sheaths at the extracellular surfaces of apposed membrane lamellae. To identify which domains of DM-20 and PLP are positioned topologically in the extracellular space to participate in adhesion, we engineered N-glycosylation consensus sites...
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