Article
Presence of human papillomavirus DNA and abnormal p53 protein accumulation in lung carcinoma.
Thorax - 1 Sept 1996
Soini Y, Nuorva K, Kamel D, Pöllänen R, Vähäkangas K, Lehto V P, Pääkkö P
Abstract excerpt
BACKGROUND: In some carcinomas inactivation of the tumour suppressor gene product p53, either by point mutation or indirectly by the human papillomavirus (HPV), has been suggested as two alternative routes to malignant transformation. To test this hypothesis in lung tumours, 43 lung carcinomas we...
Topics
- Adenocarcinoma
- Base Sequence
- Carcinoma, Squamous Cell
- DNA
- Humans
- Immunohistochemistry
- In Situ Hybridization
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Papillomaviridae
- Papillomavirus Infections
- Polymerase Chain Reaction
- Tumor Suppressor Protein p53
- Tumor Virus Infections