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Apolipoprotein E genotype and amyloid load in Alzheimer disease and control brains.

Neurobiology of aging - 1 Jan 2000

Pirttilä T, Soininen H, Mehta P D, Heinonen O, Lehtimäki T, Bogdanovic N, Paljärvi L, Kim K S, Kosunen O, Winblad B, Riekkinen P, Wisniewski H M

Abstract excerpt

We investigated the effect of apolipoprotein E (apoE) genotype on amyloid load in the frontal and cerebellar cortices of 24 patients with definite Alzheimer disease (AD) and 19 controls. Amyloid load was examined by using two methods: 1) acid-extractable amyloid beta-protein (A beta) and insoluble A beta levels of frontal and cerebellar cortices were measured by using enzyme-linked immunosorbent assay, and 2) all...

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PMID: 8983040
DOI: 10.1016/s0197-4580(96)00204-7

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