Article
Human skin fibroblasts as a model of growth hormone (GH) action in GH receptor-positive Laron's syndrome.
Endocrinology - 1 Jan 1997
Freeth J S, Ayling R M, Whatmore A J, Towner P, Price D A, Norman M R, Clayton P E
Abstract excerpt
Congenital GH insensitivity (Laron's syndrome, LS) is often associated with a dysfunctional GH receptor (GHR) causing complete insensitivity to GH and absent serum GH-binding protein (GHBP). However, a proportion of children with LS have normal GHBP levels. We have identified four girls from two families with this condition (height SD score, -3.4 to -6.8) and undertaken studies on 1) their GHR genes and 2) their...
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