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Article

Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism.

The Journal of clinical investigation - 1 Mar 1993

Edery M, Rozakis-Adcock M, Goujon L, Finidori J, Lévi-Meyrueis C, Paly J, Djiane J, Postel-Vinay M C, Kelly P A

Abstract excerpt

A single point mutation in the growth hormone (GH) receptor gene generating a Phe-->Ser substitution in the extracellular binding domain of the receptor has been identified in one family with Laron type dwarfism. The mutation was introduced by site-directed mutagenesis into cDNAs encoding the full-length rabbit GH receptor and the extracellular domain or binding protein (BP) of the human and rabbit GH receptor,...

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Source

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Identifiers

PMID: 8450064
DOI: 10.1172/JCI116304
PMCID: PMC288035

Genes

PRL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse)Semantic proximity Read ↗

Intronic mutation in the growth hormone (GH) receptor gene from a girl with Laron syndrome and extremely high serum GH binding protein: extended phenotypic study in a very large pedigree.Semantic proximity Read ↗

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