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Article

Characterization of a noncontiguous gene deletion of the growth hormone receptor in Laron's syndrome.

The Journal of clinical endocrinology and metabolism - 1 Nov 1993

Meacham L R, Brown M R, Murphy T L, Keret R, Silbergeld A, Laron Z, Parks J S

Abstract excerpt

Noncontiguous deletion of the GH receptor (GHR) gene has been described as a molecular defect causing Laron's syndrome (LS). The abnormal allele (GHR Del-3,5,6) lacks exons 3, 5, and 6. Exon 4 is retained on variant-sized restriction fragments. We studied DNA from 10 additional LS subjects of Jewish-oriental origin and found this allele in 3 samples. All subjects with this complex deletion allele were from Iran...

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Source

Identifiers

PMID: 8077336
DOI: 10.1210/jcem.77.5.8077336

Genes

GHR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of a noncontiguous gene deletion of the growth hormone receptor in Laron's syndrome.PMID 8077336Read ↗

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