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p53 down-regulates SARS coronavirus replication and is targeted by the SARS-unique domain and PL <sup>pro</sup> via E3 ubiquitin ligase RCHY1

12 Aug 2016

Abstract excerpt

Highly pathogenic severe acute respiratory syndrome coronavirus (SARS-CoV) has developed strategies to inhibit host immune recognition. We identify cellular E3 ubiquitin ligase ring-finger and CHY zinc-finger domain-containing 1 (RCHY1) as an interacting partner of the viral SARS-unique domain (SUD) and papain-like protease (PL(pro)), and, as a consequence, the involvement of cellular p53 as antagonist of...

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PMID: 27519799
DOI: 10.1073/pnas.1603435113

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