Article
Genetic control of acquired resistance to Heligmosomoides polygyrus: overcoming genetically determined weak responder status by strategic immunization with ivermectin-abbreviated infections.
Journal of helminthology - 1 Jun 1996
Wahid F N, Behnke J M
Abstract excerpt
The induction of acquired resistance to H. polygyrus, following treatment of mice by a 6 day immunizing infection abbreviated with the anthelmintic drug ivermectin (6d I-AI), was investigated. Four worms were sufficient to elicit > 80% protection against challenge and immunizing infections > 50 w...
Topics
- Animals
- Antibodies, Helminth
- Antigens, Helminth
- Antinematodal Agents
- Down-Regulation
- Female
- Immunity, Active
- Immunization
- Immunoglobulin G
- Ivermectin
- Male
- Mice
- Mice, Inbred C3H
- Mice, Inbred C57BL
- Mice, Inbred CBA
- Nematospiroides dubius
- Phenotype
- Strongylida Infections