Article
Differential effects of diet and obesity on high and low affinity sulfonylurea binding sites in the rat brain.
Brain research - 11 Nov 1996
Levin B E, Brown K L, Dunn-Meynell A A
Abstract excerpt
The brain contains neurons which alter their firing rates when ambient glucose concentrations change. An ATP-sensitive K+ (Katp) channel on these neurons closes and increases cell firing when ATP is produced by intracellular glucose metabolism. Binding of the antidiabetic sulfonylurea drugs to a site linked to this channel has a similar effect. Here rats with a propensity to develop diet-induced obesity (DIO) or...
Topics
- ATP-Binding Cassette Transporters
- Analysis of Variance
- Animals
- Brain
- Diet
- Disease Susceptibility
- Glucose
- Male
- Obesity
- Phenotype
- Potassium Channels
- Potassium Channels, Inwardly Rectifying