Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt.

doi:10.1128/jb.178.23.6952-6959.1996

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Article

Evidence that the CysG protein catalyzes the first reaction specific to B12 synthesis in Salmonella typhimurium, insertion of cobalt.

Journal of bacteriology - 1 Dec 1996

Fazzio T G, Roth J R

Abstract excerpt

The cysG gene of Salmonella typhimurium is involved in synthesis of both cobalamin (B12) and siroheme (a cofactor required for SO3(2-) and NO2(2-) reductases). The failure to reduce SO3(2-) leads to cysteine auxotrophy, for which the enzyme is named. Although Escherichia coli does not synthesize...

Topics

Chromosome Mapping
Cobalt
Culture Media
Cysteine
Heme
Iron
Methionine
Methyltransferases
Mutagenesis
Operon
Oxidation-Reduction
Phenotype
Point Mutation
Salmonella typhimurium
Sulfites
Vitamin B 12

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