Identification of Two Separate Domains in the Influenza Virus PB1 Protein Involved in the Interaction with the PB2 and PA Subunits: A Model for the Viral RNA Polymerase Structure

Abstract excerpt

The domains of the PB1 subunit of the influenza virus polymerase involved in the interaction with the PB2 and PA subunits have been defined by mutational analysis of PB1 protein. The experimental approach included in vivo competition of the PB1 activity, two-hybrid interaction assays and in vitro binding to PB1-specific matrices. Mutants of the PB1 gene including N-terminal, C-terminal and internal deletions and...

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