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Article

Disruption of the viral polymerase complex assembly as a novel approach to attenuate influenza A virus.

The Journal of biological chemistry - 11 Mar 2011

Mänz Benjamin, Götz Veronika, Wunderlich Kerstin, Eisel Jessica, Kirchmair Johannes, Stech Jürgen, Stech Olga, Chase Geoffrey, Frank Ronald, Schwemmle Martin

Abstract excerpt

To develop a novel attenuation strategy applicable to all influenza A viruses, we targeted the highly conserved protein-protein interaction of the viral polymerase subunits PA and PB1. We postulated that impaired binding between PA and PB1 would negatively affect trimeric polymerase complex forma...

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Identifiers

PMID: 21183679
DOI: 10.1074/jbc.M110.205534
PMCID: PMC3048726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21183679-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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