Article
Cloning and identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen oxidase.
Yeast (Chichester, England) - 1 Nov 1996
Glerum D M, Shtanko A, Tzagoloff A, Gorman N, Sinclair P R
Abstract excerpt
A respiratory-defective mutant (C54) of Saccharomyces cerevisiae was found to have a phenotype consistent with a mutation in either mitochondrial protoporphyrinogen oxidase or ferrochelatase. The mutant is grossly deficient in hemes, accumulates protoporphyrin and is rescued by exogenous heme. Th...
Topics
- Cloning, Molecular
- Genes, Fungal
- Genetic Complementation Test
- Heme
- Mitochondria
- Mitochondrial Proteins
- Oxidoreductases
- Oxidoreductases Acting on CH-CH Group Donors
- Oxygen Consumption
- Phenotype
- Porphyrins
- Protoporphyrinogen Oxidase
- Restriction Mapping
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Sequence Homology
- Species Specificity