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Article

Cloning and identification of HEM14, the yeast gene for mitochondrial protoporphyrinogen oxidase.

Yeast (Chichester, England) - 1 Nov 1996

Glerum D M, Shtanko A, Tzagoloff A, Gorman N, Sinclair P R

Abstract excerpt

A respiratory-defective mutant (C54) of Saccharomyces cerevisiae was found to have a phenotype consistent with a mutation in either mitochondrial protoporphyrinogen oxidase or ferrochelatase. The mutant is grossly deficient in hemes, accumulates protoporphyrin and is rescued by exogenous heme. The increased levels of protoporphyrin at the expense of heme is indicative of a block in one of the two last steps of...

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PMID: 8948097
DOI: 10.1002/(SICI)1097-0061(199611)12:14%3C1421::AID-YEA38%3E3.0.CO;2-W

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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