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Article

Identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles.

The Biochemical journal - 15 Dec 1992

Chelstowska A, Zoladek T, Garey J, Kushner J, Rytka J, Labbe-Bois R

Abstract excerpt

The molecular basis of the uroporphyrinogen decarboxylase defect in eleven yeast 'uroporphyric' mutants was investigated. Uroporphyrinogen decarboxylase, an enzyme of the haem-biosynthetic pathway, catalyses the decarboxylation of uroporphyrinogen to coproporphyrinogen and is encoded by the HEM12 gene in the yeast Saccharomyces cerevisiae. The mutations were identified by sequencing the mutant hem12 alleles...

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Identifiers

PMID: 1471989
DOI: 10.1042/bj2880753
PMCID: PMC1131950

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