Article
Identification of amino acid changes affecting yeast uroporphyrinogen decarboxylase activity by sequence analysis of hem12 mutant alleles.
The Biochemical journal - 15 Dec 1992
Chelstowska A, Zoladek T, Garey J, Kushner J, Rytka J, Labbe-Bois R
Abstract excerpt
The molecular basis of the uroporphyrinogen decarboxylase defect in eleven yeast 'uroporphyric' mutants was investigated. Uroporphyrinogen decarboxylase, an enzyme of the haem-biosynthetic pathway, catalyses the decarboxylation of uroporphyrinogen to coproporphyrinogen and is encoded by the HEM12...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Binding Sites
- Molecular Sequence Data
- Phenotype
- Point Mutation
- Saccharomyces cerevisiae
- Structure-Activity Relationship
- Uroporphyrinogen Decarboxylase