Perturbation of FliL interferes with Proteus mirabilis swarmer cell gene expression and differentiation.

Abstract excerpt

Proteus mirabilis is a dimorphic, motile bacterium often associated with urinary tract infections. Colonization of urinary tract surfaces is aided by swarmer cell differentiation, which is initiated by inhibition of flagellar rotation when the bacteria first contact a surface. Mutations in fliL, encoding a flagellar structural protein with an enigmatic function, result in the inappropriate production of...

Topics

• Amino Acid Sequence
• Bacterial Proteins
• Base Sequence
• Gene Expression Profiling
• Gene Expression Regulation, Bacterial
• Glucose
• Membrane Proteins
• Molecular Sequence Data
• Mutation
• Operon
• Proteus mirabilis
• RNA, Bacterial