Article
Metabolic models of selection response.
Journal of theoretical biology - 7 Oct 1996
Keightley P D
Abstract excerpt
Consequences of directional selection on metabolic flux are explored in models for which variation in flux among individuals is generated by segregation of allelic variants at enzyme activity loci. The pattern of selection response is strongly affected by the presence of genetic dominance and epistasis, which are automatically generated in metabolic systems. The expected magnitudes of dominance and epistasis...
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