How many phenotypes from one genotype? The case of Prion diseases.

Abstract excerpt

The usual assumption, namely that the underlying biochemical reactions in an organism tend to a unique steady-state, is shown to be not always correct. There are certain pathway mechanisms (e.g. positive feedback) which allow the system to exists in two alternative stable steady states. This bistability implies that environmental perturbations can "switch" the system from either state to the other. Such a switch...

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