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Article

Brain metastasis model in athymic nude mice using a novel MUC1-secreting human breast-cancer cell line, MA11

27 Nov 1996

Abstract excerpt

The MA11 human breast-cancer cell line was established with cells isolated from a bone-marrow sample using immunomagnetic beads conjugated to the anti-MUC1 antibody BM-2. The cell line showed a selective preference for metastasising to the brain in athymic nude mice. Following injection of MA11 cells into the left ventricle of the heart, brain metastases developed in 87% (20/23) animals, with a mean latency until...

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PMID: 8938153
DOI: 10.1002/(sici)1097-0215(19961127)68:5<682::aid-ijc20>3.0.co;2-2

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