Association between alcoholism and the dopamine D4 receptor gene.

doi:10.1136/jmg.33.2.113

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Article

Association between alcoholism and the dopamine D4 receptor gene.

Journal of medical genetics - 1 Feb 1996

Muramatsu T, Higuchi S, Murayama M, Matsushita S, Hayashida M

Abstract excerpt

A point mutation in the aldehyde dehydrogenase 2 gene (ALDH2(2) allele) is considered to be a genetic deterrent for alcoholism; however, 80 of 655 Japanese alcoholics had the mutant allele. Genotype factors that might increase susceptibility by overriding the deterrent showed a higher frequency o...

Topics

Adult
Alcoholism
Aldehyde Dehydrogenase
Alleles
Base Sequence
Female
Genes
Genetic Heterogeneity
Genetic Predisposition to Disease
Genotype
Humans
Isoenzymes
Japan
Male
Middle Aged
Molecular Sequence Data
Point Mutation
Receptors, Dopamine D2

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