Article
Association between alcoholism and the dopamine D4 receptor gene.
Journal of medical genetics - 1 Feb 1996
Muramatsu T, Higuchi S, Murayama M, Matsushita S, Hayashida M
Abstract excerpt
A point mutation in the aldehyde dehydrogenase 2 gene (ALDH2(2) allele) is considered to be a genetic deterrent for alcoholism; however, 80 of 655 Japanese alcoholics had the mutant allele. Genotype factors that might increase susceptibility by overriding the deterrent showed a higher frequency of a five repeat allele of the dopamine D4 receptor 48 bp repeat polymorphism in alcoholics with ALDH2(2) than in 100...
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