Article
Influence of the dopamine D2 receptor (DRD2) genotype on neuroadaptive effects of alcohol and the clinical outcome of alcoholism.
Pharmacogenetics - 1 Aug 1997
Finckh U, Rommelspacher H, Kuhn S, Dufeu P, Otto G, Heinz A, Dettling M, Giraldo-Velasquez M, Pelz J, Gräf K J, Harms H, Sander T, Schmidt L G, Rolfs A
Abstract excerpt
The present study was performed to test the hypotheses that allelic variants at the human dopamine D2 receptor gene locus (DRD2) confer susceptibility to alcoholism or are associated with clinical subtypes of alcoholism. We investigated an A --> G substitution polymorphism in the 3'-untranslated region of exon 8 (E8) of DRD2 with allele frequencies of f(G) = 0.295 - 0.329. No significant association of the DRD2...
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